Recruit

The Department of Radiation Oncology and Dr. Charles Limoli, Professor and Vice Chair of the Radiation Oncology Department at the University of California, Irvine anticipates a postdoctoral position opening available for 2-3 years funded by National Institutes of Health (NIH). Salary will be commensurate with experience. The scholar will be responsible for investigating the efficacy of radiation- and/or chemotherapy-induced tumor cell kill and normal tissue sparing in the CNS and other peripheral organ sites. Our laboratory employs cutting edge cancer therapy paradigms with a focus on ultra-high dose rate “FLASH” radiotherapy, gene silencing, transgenic, stem cell-based and pharmacological approaches to study neurobiological mechanisms and regenerative strategies to ameliorate a wide range of normal tissue toxicities, neuroinflammation and cognitive impairments.

Requirements: The successful candidate will possess an excellent track record and a high level of motivation to conduct independent experiments and work well with a team. This position will play an integral role in the execution of the overall aims of several funded NIH grants focused on the translational potential of FLASH radiotherapy, stem cell and extracellular vesicles based strategies to enhance the therapeutic index of cancer treatments in the CNS, lung and head and neck. The candidate will also be expected to be familiar with statistics and the analysis and preparation of data sets for presentations in scientific meetings and peer-reviewed publications.

• Must have hands-on experience with mice or rat handling, rodent behavior and cognitive function.
• Must have experience in standard molecular and cell biology techniques (i.e. cell culture, immunohistochemistry, ELISA, Western blot, RNA, DNA, etc.).
• Must possess strong skills in organization, data handling and statistical analysis. Must have proficiency in English with excellent oral, written, and interpersonal communication skills.
• Must have experience in supervising/training students and research staff.
• Brain and/or peripheral cancer induction (orthotopic and flank cancer models), cancer imaging (BLI, CBCT, MRI).
• Hands on experience with mouse and/or rat stereotaxic surgery.
• Mammalian cell culturing (human or rodent stem cells, cancer cells), isolation and characterization of extracellular vesicles (exosomes).
• Confocal and/or Super-Resolution microscopy, and 3D fluorescent image quantification techniques (i.e. Imaris, Auto Quant, ClearView, Neurolucida, Stereology).
• Knowledge of genetic manipulation of mammalian cells and mouse brain to knockdown or overexpress genes (i.e AAV, Lentivirus, CRISPR-Cas, Cre-LoxP).
• Electrophysiology and machine learning experience would be advantageous.

Send curriculum vitae with the names and addresses of three references (please do not solicit letters) to:

Charles Limoli, Professor
Vice Chair of Research and Academic Affairs
Department of Radiation Oncology
Medical Sciences I, B-146B
University of California
Irvine, California 92697-2695

Please complete your application by also submitting a statement on previous and/or past contributions to diversity, equity and inclusion.

This position is dependent on extramural funds and may be subjected to the disposition/availability of such funds. The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

Qualified candidates can apply at: https://recruit.ap.uci.edu/apply/JPF8005

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.