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Project Scientist - Neurotherapeutics Institute

Position overview

Salary range: A reasonable estimate for this position is $68,400-$180,200. See “Off-scale salaries” and other components of pay, i.e., a salary that is higher than the published system-wide salary at the designated rank and step, are offered when necessary to meet competitive conditions.

Application Window

Open January 30, 2023 through Friday, Jun 30, 2023 at 11:59pm (Pacific Time)

Position description

We seek a doctorate level or equivalent degree project scientist with substantial experience using computer aided drug (CADD) design techniques to guide library screening and lead optimization efforts. The ideal candidate will have ample experience with diverse tools in a pharmaceutical industry context or similar, with a thorough understanding of the available methods and their pros and cons, as well as experience interacting with both academic and industry collaborators in a discovery setting. In this position, the project scientist will engage in modeling efforts to guide ongoing screening and lead optimization work, as well as engaging with graduate student and postdoctoral researchers in participating computational labs to help them engage in ongoing modeling efforts and bring new techniques to bear in screening.
In this role, the project scientist will provide a hub or bridge between different experimental efforts and available computational resources, both those the project scientist can provide through their own expertise and skill, and those available elsewhere on campus, such as in the Mobley lab. The project scientist will work under the oversight of Dr. Mobley but engage frequently (ideally sharing space with and continually engaging with) the participating experimental groups to provide ongoing modeling guidance to discovery projects, with the goal of tightly integrating modeling and experiment.

PREFERRED QUALIFICATIONS (but not required for the position)
A candidate should have experience with diverse technologies and tools in the CADD space, including:
● Virtual screening techniques (fingerprinting, docking, shape-based, pharmacophore modeling, etc.)
● Tools for guiding lead optimization, including potentially molecular dynamics simulations, binding free energy calculations, QSAR modeling, etc.
● Substantial skill with structure-based design, including ample experience preparing/validating protein structures for modeling, assessing/assigning protonation states, building in missing residues/loops, etc.
● Experience with building/using homology models
● Experience working with medicinal chemists and considering synthetic accessibility and metabolic issues would be a significant plus

Other preferred qualifications include:
● Excellent Python skills
● Scientific software development experience
● Familiarity with open source software development, continuous integration testing, etc.
● Experience with git and version control systems, e.g. including GitHub
● Experience working with both academic and vendor-supported software
● Comfortable working with diverse high performance computing resources and queueing systems in a Linux-based environment
● Comfortable using, and building workflows with, diverse software types including GUI-based, command-line-based and API-based frameworks.

A reasonable estimate for this position is $68,400-$180,200. “Off-scale salaries” and other components of pay, i.e., a salary that is higher than the published system-wide salary at the designated rank and step, are offered when necessary to meet competitive conditions.

To apply, please log into: UCI Recruit: to upload Cover letter, CV and Inclusive Excellence/Contributions to Diversity Statement.


Basic qualifications (required at time of application)

• A Ph.D. or equivalent degree is required for this position.

Application Requirements

Document requirements
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Campus Information

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

As a condition of employment, you will be required to comply with the University of California Policy on Vaccination Programs – With Updated Interim Amendments. All Covered Individuals under the policy must provide proof of receiving the COVID-19 Vaccine Primary Series or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, Religious Objection, and/or Deferral based on pregnancy or recent COVID-19 diagnosis and/or treatment) no later than the applicable deadline. All Covered Individuals must also provide proof of receiving the most recent CDC-recommended COVID-19 booster or properly decline such booster no later than the applicable deadline. New University of California employees should refer to Exhibit 2, Section II.C. of the SARS-CoV-2 (COVID-19) Vaccination Program Attachment for applicable deadlines. All Covered Individuals must also provide proof of being up-to-date on seasonal influenza vaccination or properly decline such vaccination no later than the applicable deadline. Please refer to the Seasonal Influenza Vaccination Program Attachment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.

Job location

Irvine, Ca.