Multi-omics Postdoctoral Fellowship - Ng Lab
Open date: April 14, 2023
Most recent review date: Wednesday, May 31, 2023 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.
Final date: Sunday, Mar 31, 2024 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
A postdoctoral position is available at the University of California, Irvine under the leadership of Dr. Stanley Ng. The successful candidate will explore the relationship between the hierarchy of molecular layers from epigenome to phenome at clonal resolution in various tissues. In brief, studies will involve the generation of multiple data modalities from human and mouse tissue clones, including spatially-resolved somatic DNA mutations, gene and protein expression, and methylation profiles. Bioinformatic integration of distinct data types and subsequent statistical analyses will be performed to elucidate how alterations to various molecular layers in individual clones can lead to their respective contributions to disease development/progression, malignant transformation, and treatment-specific resistance. Thus, these studies will facilitate the identification of novel risk markers and therapeutic targets. The development of minimally-invasive and clinically-relevant biofluid-based molecular risk and treatment response predictors using statistical models will also be investigated, with the goal of clinical translation.
We are seeking candidates who are interested in developing novel diagnostic tools and identifying tailored disease-clone specific targeting strategies. Successful candidates will be expected to work independently, while collaborating with bioinformaticians, biologists, clinicians, and other scientists as appropriate to achieve scientific aims.
Our lab employs bleeding-edge computational platforms and state-of-the-art omics technologies. UC Irvine is a world-class research university with highly ranked graduate programs in biomedical sciences. Our Southern California location is home to one of the largest academic research and biotechnology hubs in the US. Lab members enjoy direct access to this outstanding community of clinicians and scientists, as well as the wide range of recreational activities available in our region. Successful candidates will join an interdisciplinary and highly collaborative team working to develop the next generation of tools and technologies to advance precision diagnostics and therapeutics.
• A PhD or MD/PhD degree with a focus on Epigenetics, Genetics, Genomics, Biology, Bioinformatics, Machine Learning, or a related field
• Extensive experience in a research environment and at least 1 first-author publication in a reputable scientific journal
• Proficiency in R, Python, and/or other programming languages, and familiarity with working in a Linux-based high-performance computing environment
• Formal training and expertise in statistical model development and the analysis of high-dimensional data, including next generation sequencing datasets
• Ability to work independently to drive projects forward
• Ability to communicate effectively and collaborate as part of a multidisciplinary team
• Ability to compose and deliver comprehensive presentations at scientific meetings and prepare research articles for peer-reviewed publications
• Experience with sectioning, fixing, and staining tissues for histology imaging, laser capture microdissection, and sample prep for (single-cell) sequencing
• Expertise with ATAC-Seq, methylation profiling, genome/exome/targeted sequencing, mutation calling, single-cell analysis, RNA-Seq, proteomics, biofluids analysis, spatial technologies from 10X, NanoString, or similar
• Expertise in machine learning and mathematical/statistical inference (e.g., image classification using deep neural networks, reinforcement learning, regularized regression and classification models, clustering, optimization)
• Experience with multi-omic data generation and integrative analysis (e.g., 10X Multiome, Mission Bio Tapestri, custom-built computational pipelines)
• Expertise with multi-core/multi-threaded parallelization using GPU-based hardware acceleration or similar
• Experience with building highly distributable software (e.g., R packages, Python modules, Linux-based command-line tools, C programs, MATLAB applications, GitHub)
Salary will be based on University of California guidelines for Postdoctoral scholars and is commensurate with qualifications and experience. Appointments will be for up to 3 years, and will be funded by extramural awards.
For additional information about the research program and this opportunity, please contact Dr. Ng at firstname.lastname@example.org.
A PhD or MD/PhD degree with a focus on Epigenetics, Genetics, Genomics, Biology, Bioinformatics, Machine Learning, or a related field
Curriculum Vitae - Your most recently updated C.V.
Cover Letter (Optional)
Statement of Research - Describe prior experience, future goals, and how you can contribute to the overall research vision of the Ng laboratory
Inclusive Excellence Activities Statement - Statement addressing how past and/or potential contributions to inclusive excellence will advance UCI's Commitment to Inclusive Excellence. See our guidance for writing an inclusive excellence activities statement.
Misc / Additional (Optional)
- 3-5 required (contact information only)
The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
As a condition of employment, you will be required to comply with the University of California Policy on Vaccination Programs – With Updated Interim Amendments. All Covered Individuals under the policy must provide proof of receiving the COVID-19 Vaccine Primary Series or, if applicable, submit a request for Exception (based on Medical Exemption, Disability, Religious Objection, and/or Deferral based on pregnancy or recent COVID-19 diagnosis and/or treatment) no later than the applicable deadline. All Covered Individuals must also provide proof of receiving the most recent CDC-recommended COVID-19 booster or properly decline such booster no later than the applicable deadline. New University of California employees should refer to Exhibit 2, Section II.C. of the SARS-CoV-2 (COVID-19) Vaccination Program Attachment for applicable deadlines. All Covered Individuals must also provide proof of being up-to-date on seasonal influenza vaccination or properly decline such vaccination no later than the applicable deadline. Please refer to the Seasonal Influenza Vaccination Program Attachment. (Capitalized terms in this paragraph are defined in the policy.) Federal, state, or local public health directives may impose additional requirements.